Effet of Chlordecone on Rat Brain Parts Cnos Activity Livels in Vivo
نویسنده
چکیده
In view of the neurotoxic effects induced by chlordecone an attempt is made to study the in vivo effect of this organic insecticide on rat brain based nitric oxide synthase (NOS) activity. Rats cerebellum, hypothalamus, midbrain, straiatum, hippocampus, cerebral cortex and medulla oblongate receiving sub-lethal and lethal doses of chlordecone showed decreased levels of their constitutive NOS activity and the changes were found to be statistically significant (p<0.001) over the control. Since cNOS activity in dependent on calcium / calmodulin, interaction of chlordecone with Ca2+/ CaM mediated events might be the reason for inhibition of cNOS activity of various brain parts of rats.
منابع مشابه
Reduction in Aluminum Induced Oxidative Stress by Meloxicam in Rat Brain
Background: Non-steroidal anti-inflammatory drugs (NSAID) have been associated with antioxidant property and have been shown to improve the circulating antioxidant status on daily dosing in different inflammatory conditions. The present study was conducted to investigate the antioxidant role of meloxicam in aluminum induced oxidative stress in rat brain. Methods: In the in vivo experiments, Spr...
متن کاملIn Vitro Antioxidant and Hepatoprotective Activity of Ethanolic Extract of Bacopa monnieri Linn. Aerial Parts
The ethanol extract of Bacopa monnieri Linn. (Schrophulariaceae) aerial parts (EBM) was investigated for any in vitro and in vivo antioxidant and hepatoprotective effects. EBM was prepared and estimation of total phenolics was carried out. Further, the antioxidant activity of EBM was studied using four in vitro models. The amount of total phenolics was estimated to be 47.7 (g of pyr...
متن کاملEstrogenic activity of the insecticide chlordecone (Kepone) and interaction with uterine estrogen receptors.
The chlorinated insecticide chlordecone (Kepone) interacts with the estrogen receptor system in the rat uterus in vitro and in vivo. It competes with estradiol for binding to the cytoplasmic receptor in vitro and also induces nuclear accumulation of estrogen receptor sites in uteri in vitro. When injected into immature rats, chlordecone translocates estrogen receptor sites to the uterine nucleu...
متن کاملAnti-inflammatory effects of essential oil, aerial parts and hairy roots extracts of Nepeta pogonosperma on rat brain mixed cells
Background and objectives: Many Nepeta species have been commonly used in Iranian folk medicine as tranquilizer, relaxant, carminative and restorative tonic for nervous and respiratory disorders. Inflammation is a problem in many diseases and has an important role in brain function that can cause neurodegenerative disorders. Inflamed glial cells can exacerbate neurodegenerative disease...
متن کاملGM1 ganglioside enhances synaptosomal resistance to chemically induced damage.
A neurotoxic agent, chlordecone, damages the limiting membrane of isolated synaptosomes prepared from rat brain. This is shown by increased levels of free, ionic calcium and increased permeability of synaptosomes, using the fluorimetric probe, fura-2. Pretreatment of synaptosomes with the monosialoganglioside GM1, attenuates the effect of chlordecone. A parallel preincubation of synaptosomes wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014